Prostin E2

Prostin E2

dinoprostone

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Dinoprostone
Indications/Uses
Induction of labour especially in patients w/ favourable induction features.
Dosage/Direction for Use
Initially, insert 1 tab (3 mg) high into posterior fornix. 2nd tab may be inserted after 6-8 hr if labor is not established. Max: 6 mg in 24 hr.
Contraindications
Hypersensitivity to dinoprostone or prostaglandins. History of caesarean section or major uterine surgery; cephalopelvic disproportion, foetal malpresentation is present; pre-existing foetal distress; history of difficult labour &/or traumatic delivery; unexplained vag discharge & bleeding &/or abnormal uterine bleeding; evidence of placenta praevia. Patients w/ pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.
Special Precautions
Asthma or history of asthma, epilepsy or history of epilepsy, glaucoma or raised IOP, compromised CV, hepatic or renal function, HTN, ruptured chorioamniotic membranes; known history of hypertonic uterine contractility or tetanic uterine contractions; patients w/ multiple pregnancy. Monitor uterine activity, fetal heart rate & cervical dilation during therapy. Evaluate cephalopelvic relationships prior to use. Women ≥35 yr & w/ gestational age >40 wk. Not to be used during pregnancy.
Adverse Reactions
Hypersensitivity reactions; diarrhea, nausea, vomiting; back pain; uterine contractile abnormalities & rupture, abruptio placenta, pulmonary amniotic fluid embolism, rapid cervical dilatation; warm feeling in vag; fever; HTN; asthma, bronchospasm; foetal & neonatal death, still births; fetal distress/altered fetal heart rate, neonatal distress/low Apgar score.
Drug Interactions
Accentuated response w/ exogenous prostaglandin therapy. Not recommended in concurrent use w/ other oxytocic agents.
MIMS Class
Drugs Acting on the Uterus
ATC Classification
G02AD02 - dinoprostone ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Presentation/Packing
Form
Prostin E2 vag tab 3 mg
Packing/Price
4's
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