Prograf Caution For Usage

Instructions for Use/Handling: Capsules should be taken immediately following removal from the blister. Patients should be advised not to swallow the desiccant.
Tubing, syringes and other equipment used to administer Prograf should not contain PVC (see Incompatibilities as follows).
Prograf Concentrate for Infusion must not be injected undiluted.
Prograf Concentrate for Infusion should be prepared for infusion with 5% dextrose solution or physiological saline in polyethylene, polypropylene or glass containers. Only transparent and colorless solutions should be used.
The concentration of a solution for infusion should be within the range 0.004 - 0.100 mg/ml. The total volume of infusion during a 24-hour period should be in the range 20 - 500 ml.
Incompatibilities: When diluting, this medicinal product must not be mixed with other medicinal products except those mentioned in Instructions for Use/Handling. Tacrolimus is not compatible with PVC. Tubing, syringes and any other equipment used to prepare and administer Prograf concentrate for infusion or a suspension of Prograf capsule contents should not contain PVC.
Tacrolimus is unstable under alkaline conditions. Combination of the reconstituted Prograf concentrate for infusion 5mg/ml with other pharmaceutical products that produce a marked alkaline solution (e.g., acyclovir and ganciclovir) should be avoided.