Prochlorperazine - oral

Patient Medicine Information
Why do I need this medicine?
Prochlorperazine is used to treat nausea and vomiting.

It is also used to manage mood and behavioural changes in some psychiatric conditions such as schizophrenia, bipolar disorder and other psychoses.

Prochlorperazine is also used as an adjunct for the management of anxiety.
How do I take this medicine?
Take Prochlorperazine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food.

Prochlorperazine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking Prochlorperazine unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, inform your doctor or pharmacist.
When should I not use this medicine?
Prochlorperazine is not suitable for patients with dementia-related psychosis.

Do not give this medicine to children below 2 years old unless instructed to do so by the doctor.

Prochlorperazine may not be suitable for you if you are taking drugs that can cause drowsiness or affect your concentration e.g. alcohol, barbiturates and group of medicines known as phenothiazines.
What should I take note of while taking this medicine?
Inform your doctor if you have:
  • heart disease
  • kidney disease
  • liver disease
  • Parkinson's disease (a brain disease that affects movement)
  • thyroid disease
  • enlarged prostate
  • myasthenia gravis (a condition that causes muscle weakness)
  • phaechromocytoma (tumour in the adrenal glands)
  • glaucoma (high pressure in the eyes)
  • seizures (fits)
  • stroke or history of stroke
  • blood clots or family history of blood clots
Let your doctor know if you are pregnant or breastfeeding.

If you are going for an operation, including minor operations and dental work, inform your doctor or dentist that you are being treated with Prochlorperazine.

Your doctor may need to do blood tests to make sure that your blood counts are normal if you're taking Prochlorperazine for long-term. You will be advised about how often you need to have these blood tests by your doctor.
What side effects could I experience?
Prochlorperazine may cause drowsiness or dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

You may experience dizziness when getting up from a sitting or lying down position, especially if you are taking Prochlorperazine for the first time. This is normal and should disappear gradually as you get used to the medicine. It will help if you get up slowly from a sitting or lying position.

Other side effects include any of the following: headache, constipation, dry mouth, blurred vision, tiredness, weakness, anxiety, weight gain, difficulty in sleeping, and agitation.

Your skin may become more sensitive to sunlight. Try to avoid the sun. Apply sunblock, use an umbrella or wear a hat to minimise sunlight exposure if you do go out under the sun.

Other side effects may need immediate medical help. Alert your doctor immediately if you experience any of the following:
  • fast or irregular heartbeat
  • feeling of restlessness or involuntary, repetitive body movement
  • muscle stiffness, high fever, excessive sweating, altered mental status
  • yellowing of the eyes or skin
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines?
Do not take Prochlorperazine if you are taking any medicines that can cause drowsiness or affect your concentration e.g. barbiturates, opioids.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for mood or psychiatric problems e.g. lithium, haloperidol
  • medicines used to treat Parkinson's disease e.g. levodopa
  • medicines which affect heart rhythm such as quinidine, sotalol, procainamide, dronedarone
  • medicines to treat high blood pressure and heart disease e.g. propranolol, clonidine, diltiazem, verapamil
  • desferrioxamine (a medicine to remove excess iron in the blood)
  • medicines to treat cancer e.g. procarbazine
  • other medicines such as erythromycin (antibiotic) and halofantrine (medicine to treat malaria)
This list does not include all medicines that may interact with Prochlorperazine.

Prochlorperazine must not be taken together with antacids. If you must take antacids, take between meals at least 2 hours after you have taken Prochlorperazine.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

This information is independently developed by MIMS based on prochlorperazine - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
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