View Pristiq overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Take at the same time each day. Swallow whole, do not divide/crush/chew/dissolve tab.
Contraindications
Hypersensitivity to desvenlafaxine succinate, venlafaxine HCl. Concomitant use or w/in 14 days of discontinuing treatment w/ MAOI. Patients being treated w/ reversible MAOI eg, linezolid or in whom IV methylene blue has been administered.
Monitor patients for clinical worsening, suicidality or unusual change in behaviour. Serotonin-syndrome or NMS-like reactions. History of or family history of mania/hypomania; seizure disorders. Patients w/ raised IOP or at risk of acute narrow-angle glaucoma; underlying conditions that may be compromised by increased BP; CV, cerebrovascular or lipid metabolism disorders; increased risk of bleeding; hyponatremia. Control pre-existing HTN before treatment. May cause symptoms of sexual dysfunction. Regularly monitor BP & measure serum lipids during treatment. Avoid abrupt discontinuation. Not to be used concomitantly w/ venlafaxine HCl or other desvenlafaxine succinate-containing drugs. Not recommended to used concomitantly w/ serotonin precursors eg, tryptophan supplements. Concomitant use of aspirin, NSAIDs, warfarin, other anticoagulants; diuretics. May affect ability to drive & use machines. Pregnancy & lactation. Ped <18 yr. Elderly.
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