Reduced clearance w/ CYP2D6, CYP3A4 & flavin monooxygenase I inhibitors. Increased Cmax
& AUC w/ ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir, atazanavir, fluoxetine. Increased exposure by erythromycin, clarithromycin, fluconazole, amprenavir, fosamprenavir, aprepitant, verapamil, diltiazem. Reduced orthostatic tolerance & resulted in orthostatic hypotension w/ PDE5 inhibitors, α-adrenergic receptor antagonists. Increased Cmax
& AUC of desipramine. Deceased AUCinf
of midazolam. Bleeding abnormalities w/ SSRIs. Increased somnolence & significantly decreased self-rated alertness w/ ethanol.