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General: Patients should always be monitored carefully in order to guard against the possibility of circulatory overload. Plasbumin-25 is hyperoncotic, therefore, in the presence of dehydration, albumin must be given with or followed by addition of fluids.
In hemorrhage the administration of albumin should be supplemented by the transfusion of whole blood to treat the relative anemia associated with hemodilution. When circulating blood volume has been reduced, hemodilution following the administration of albumin persists for many hours. In patients with a normal blood volume, hemodilution lasts for a much shorter period.
The rapid rise in blood pressure which may follow the administration of a colloid with positive oncotic activity necessitates careful observation to detect and treat severed blood vessels which may not have bled at the lower blood pressure.
Drug Interactions: Plasbumin-25 is compatible with whole blood, packed red cells, as well as the standard carbohydrate and electrolyte solutions intended for intravenous use. It should, however, not be mixed with protein hydrolysates, amino acid solutions nor those containing alcohol.
Use in Pregnancy: Pregnancy Category C: Animal reproduction studies have not been conducted with Plasbumin-25. It is also not known whether Plasbumin-25 can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Plasbumin-25 should be given to a pregnant woman only if clearly needed.
Pediatric Use: Safety and effectiveness in the pediatric population have not been established.
