Hypersensitivity to the active substance, to any of the excipients or to any other ACE inhibitor.
History of angioedema associated with previous ACE inhibitor therapy (see PRECAUTIONS).
Hereditary or idiopathic angioedema.
Second and third trimesters of pregnancy (see PRECAUTIONS and USE IN PREGNANCY & LACTATION).
Concomitant use of Perinace with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see INTERACTIONS and PHARMACOLOGY: PHARMACODYNAMICS under ACTIONS).
Concomitant use with sacubitril/valsartan (see PRECAUTIONS and INTERACTIONS).
Extracorporeal treatments leading to contact of blood with negatively charged surfaces (see INTERACTIONS).
Significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney (see PRECAUTIONS).