Periciazine - oral

Patient Medicine Information
Why do I need this medicine?
Periciazine is used to treat schizophrenia. It helps relieve symptoms common in schizophrenia, such as distorted thinking and emotional instability.

This medicine is also used to treat other mood-related disorders such as a general feeling of anxiousness, agitation, violent or impulsive behaviour.
How do I take this medicine?
Take Periciazine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Try to take it at the same time each day.

Periciazine is available as a tablet or syrup.

If you are taking the tablet, swallow it whole with a glass of water.

If you are taking an oral syrup, shake the bottle well before you take it to ensure that the liquid is evenly mixed. Use the measuring spoon or cup provided to measure your dose.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition.

This medicine must be taken regularly for it to be effective. Continue taking Periciazine even when you feel better. Do not stop taking it suddenly as this may worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • Parkinson’s disease (a disorder that affects the movement of a person, causing symptoms such as tremors, muscle stiffness, slowed movement and impaired balance or walking)
  • untreated fits or seizure
  • glaucoma (increased pressure in the eye)
  • phaeochromocytoma (a rare tumour of the adrenal gland causing high blood pressure)
  • myasthenia gravis (muscle weakness disorder)
  • hypothyroidism (low levels of thyroid hormones)
  • prostate enlargement
  • liver disease
  • kidney disease
as Periciazine may not be suitable for you.

If you are going for a surgical procedure where you have to undergo anaesthesia administered in the spine, inform your doctor that you are taking Periciazine.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • heart disease
  • electrolyte imbalance
  • bowel disorder
  • paralytic ileus (a condition where the bowel does not work properly)
  • urinary retention (inability to completely empty the bladder when urinating)
  • lung disease
  • Alzheimer's disease (a progressive disease which destroys memory and other important mental functions)
  • dementia (a group of symptoms affecting thinking and social abilities)
  • diabetes
  • recent brain injury
  • breast cancer
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving Periciazine to a child. Children may be more sensitive to the side effects.

Periciazine is not suitable for elderly with dementia-related psychosis.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Routine tests (e.g. CBC, liver/kidney function, cholesterol/sugar/electrolyte levels, eye examination) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
  • Regular monitoring of weight, mental status may also be needed.
What lifestyle changes should I make?

Periciazine may affect the ability of your body to adjust to temperature changes in the environment. Avoid exposure to very cold or very hot environments. Avoid strenuous exercise and activities like going to the sauna. Drink more water to prevent dehydration.
What side effects could I experience?
This medicine may cause drowsiness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: dry mouth, nausea, constipation, diarrhoea, increased appetite, headache, dizziness, and rashes.

This medicine may cause your blood pressure to fall suddenly when you get up from a sitting or lying down position and you may feel giddy. To minimise this problem, stand up slowly.

Periciazine may also make your skin more sensitive to sunlight. Apply sunscreen when going outdoors and avoid prolonged exposure to sunlight and UV lamps.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for irregular heartbeat e.g. amiodarone
  • other medicine for mood disorders e.g. lithium, amitriptyline
  • medicines for high blood pressure e.g. clonidine, guanethidine
  • medicines used to treat Parkinson’s disease e.g. levodopa
  • medicines for fits or seizures e.g. carbamazepine, phenobarbital
  • medicines that reduce stomach acid production
This list does not include all medicines that may interact with Periciazine.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol. Alcohol intake may worsen the dizziness and drowsiness caused by Periciazine.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Protect from light.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on periciazine - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
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