Paxlovid

4 pink tab each containing Nirmatrelvir 150 mg, 2 white tab each containing Ritonavir 100 mg

Covid-19 in adults who do not require supplemental O₂ & are at increased risk for progression to severe Covid-19.

300 mg/100 mg bd for 5 days. Moderate renal impairment 150 mg/100 mg bd for 5 days.

May be taken with or without food: Swallow whole, do not chew/break/crush.

History of clinically significant hypersensitivity. Concomitant use of medicinal products w/ highly dependent CYP3A clearance, potent CYP3A inducers. Severe hepatic or renal impairment.

Resistance to HIV PIs in individuals w/ uncontrolled or undiagnosed HIV-1 infection. Not to be taken by patients w/ galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Concomitant use w/ CYP3A inhibitors or inducers, CYP3A-metabolised medicinal products. Not recommended in severe renal impairment or renal failure. Pre-existing hepatic diseases, hepatic enzyme abnormalities or hepatitis. Not recommended in women of childbearing potential not using effective contraception & during pregnancy. Not to be used during lactation & 7 days after last dose. Paed patients <18 yr.

Dysgeusia; diarrhoea, vomiting.

Increased plasma conc of alfuzosin; norpethidine, piroxicam, propoxyphene, buprenorphine, norbuprenorphine, fentanyl; ranolazine; neratinib, venetoclax, afatinib, abemaciclib, apalutamide, ceritinib, dasatinib, nilotinib, vincristine, vinblastine, encorafenib, fostamatinib, ibrutinib; amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, quinidine, digoxin; fusidic acid, rifabutin, ketoconazole, itraconazole, erythromycin, bedaquiline, clarithromycin; colchicine; astemizole, terfenadine, fexofenadine, loratadine; lurasidone, pimozide, clozapine, quetiapine, haloperidol, risperidone, thioridazine; ergot derivatives eg, dihydroergotamine, ergonovine, ergotamine, methylergonovine; cisapride; lovastatin, simvastatin, atorvastatin, fluvastatin, pravastatin, rosuvastatin, lomitapide; avanafil, vardenafil, sildenafil, tadalafil; clonazepam, diazepam, estazolam, flurazepam, triazolam, midazolam; amphetamine & derivatives eg, methylphenidate, dexamefetamine; apixaban, dabigatran, rivaroxaban, vorapaxar; imipramine, amitriptyline, nortriptyline, fluoxetine, paroxetine, sertraline, desipramine; amprenavir, atazanavir, darunavir, fosamprenavir; efavirenz, maraviroc; salmeterol; amlodipine, diltiazem, nifedipine; bosentan, riociguat; glecaprevir/pibrentasvir; cyclosporine, tacrolimus, everolimus; alprazolam, buspirone; zolpidem; dexamethasone, prednisolone. Decreased plasma conc of methadone, morphine; theophylline; R-warfarin; divalproex, lamotrigine; voriconazole, atovaquone; raltegravir, zidovudine; ethinyl estradiol; bupropion. Decreased plasma conc w/ carbamazepine, phenobarb, phenytoin; rifampicin; St. John's wort (Hypericum perforatum).

Antivirals

J05AE30 - nirmatrelvir and ritonavir ; Belongs to the class of protease inhibitors. Used in the systemic treatment of viral infections.

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