Hypersentivity to the active ingredients. Acute hepatitis. It should be given with care to patients with impaired kidney or liver function, also patients taking other drugs that affect the liver.
In children below the age of 12 years for the symptomatic treatment of colds due to an increased risk of developing serious and life-threatening adverse reactions.
In all paediatric patients (0-18 years of age) who undergo tonsillectomy or adenoidectomy for obstructive sleep apnoea syndrome due to increased risk of developing serious and life-threatening adverse reactions.
In women who are breastfeeding.
In patients for whom it is known they are CYP2D6 ultra-rapid metabolisers.