Paracil Use In Pregnancy & Lactation

Fertility: Chronic toxicity studies in animals have shown that high doses of acetaminophen cause testicular atrophy and inhibition of spermatogenesis; the relevance of this finding to use in humans is not known.
Pregnancy: Problems in humans have not been documented: however, controlled studies have not been done. Risk-benefit must be considered because acetaminophen crosses the placenta.
Breast-feeding: 650 mg tab: Problems in humans have not been documented. Although peak concentrations of 10 to 15 mcg per mL (66.2 to 99.3 micromoles/L) have been measured in breast milk 1 to 2 hours following maternal ingestion of a single 650 mg dose, neither paracetamol nor its metabolites were detected in the urine of the nursing infants. The half-life in breast milk is 1.35 to 3.5 hours.
500 mg tab & oral susp: Problems in human have not been documented; however, risk-benefit must be considered. Although peak concentrations of 10 to 15 mcg maternal ingestion of a single dose 650 mg dose, neither acetaminophen nor its metabolites were detected in the urine of the nursing infants. The half-life in breast milk is 1.35 to 3.5 hours.