Paracil Drug Interactions

Alcohol or hepatic enzyme-inducers or hepatoxic medications, other: Risk of hepatoxicity with single toxic doses or prolonged use high doses acetaminophen may be increased in chronic alcoholics or in patients regularly taking other hepatotoxic medications or hepatic enzyme-inducing agents.
Chronic use of barbiturates (except butalbital) or primadone has been reported to decrease the therapeutic effects of acetaminophen, probably because in increased metabolism resulting from induction of hepatic microsomal enzyme activity; the possibility should be considered that similar effects may occur with other hepatic enzyme inducing medications.
Anticoagulants, coumarin or indandione-derivative: Concurrent chronic, high dose administration of acetaminophen may increase the anticoagulant factors; anticoagulant dosage adjustment based on increased monitoring of prothrombin time may be necessary when chronic, high dose acetaminophen therapy is initiated or discontinued; however, this does not apply to occasional use or to chronic use of doses below 2 grams per day of acetaminophen.
500 mg tab & oral susp: Combination containing any of the following medications, depending on the amount present may also interact with this medication.