Pregnancy: A moderate amount of data on pregnant women (between 300-1000 pregnancy outcomes) indicate no malformative or foeto/neonatal toxicity of pantoprazole. Animal studies have shown reproductive toxicity.
As a precautionary measure, it is preferable to avoid the use of pantoprazole during pregnancy.
Breast-feeding: Animal studies have shown excretion of pantoprazole in breast milk.
There is insufficient information on the excretion of pantoprazole in human milk but excretion into human milk has been reported. A risk to the newborns/infants cannot be excluded.
Therefore, a decision on whether to discontinue breast-feeding or to discontinue/abstain from pantoprazole therapy taking into account the benefit of breast-feeding for the child, and the benefit of pantoprazole therapy for the woman.
Fertility: There was no evidence of impaired fertility following the administration of pantoprazole in animal studies.