Pantoprazole Sandoz Dosage/Direction for Use

Posology and Method of Administration: Tablets should not be chewed or crushed, and should be swallowed whole 1 hour before a meal with some water.
Tablets should not be chewed or crushed, and should be swallowed whole 1 hour before a meal with some water.
Reflux esophagitis: One tablet of Pantoprazole 40 mg per day. In individual cases, the dose may be doubled (increase to 2 tablets of Pantoprazole 40 mg daily) especially when there has been no response to other treatment.
Eradication of H. pylori in Combination with Appropriate Antibiotics: In cases of duodenal or gastric ulcer in which infection with Helicobacter pylori has been confirmed, the microorganism should be eradicated by combination treatment.
Depending upon the resistance pattern, the following combinations can be recommended: One pantoprazole 40-mg tab twice daily + amoxicillin 1000 mg twice daily + clarithromycin 500 mg twice daily; One pantoprazole 40-mg tab twice daily + metronidazole 500 mg twice daily + clarithromycin 500 mg twice daily; One pantoprazole 40-mg tab twice daily + amoxicillin 1000 mg twice daily + metronidazole 500 mg twice daily.
Treatment of gastric and duodenal ulcer: One tablet of Pantoprazole 40 mg per day. In individual cases, the dose may be doubled (increase to 2 tablets of Pantoprazole 40 mg daily) especially when there has been no response to other treatment.
Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions: For the long-term management of Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions patients should start their treatment with a daily dose of 80 mg (2 tablets of Pantoprazole 40 mg). Thereafter, the dose can be titrated up or down as needed using measurements of gastric acid secretion to guide. With doses above 80 mg daily, the dose should be divided and given twice daily. A temporary increase of the dose above 160 mg pantoprazole is possible but should not be applied longer than required for adequate acid control. Treatment duration in Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions is not limited and should be adapted according to clinical needs.
Type and duration of treatment: Combination therapy for eradication of Helicobacter pylori infection usually lasts 7 days and can be extended to a maximum of 2 weeks. If after this time further treatment with Pantoprazole 40 mg is indicated to ensure that the ulcer heals completely, the dose recommendations for gastric and duodenal ulcers must be observed.
In the majority of cases, a duodenal ulcer heals completely within 2 weeks. If a two-week treatment period is not sufficient, healing will be achieved in almost all cases within a further 2 weeks.
Gastric ulcers and reflux esophagitis usually require a 4-week course of treatment. If this should be inadequate, healing will in most cases be achieved within a further 4 weeks. Treatment should not exceed 8 weeks as experience with long-term use is limited.
Treatment duration in Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions is not limited and should be adapted according to clinical needs.
Children below 12 years of age: Pantoprazole 40 mg is not recommended for use in children below 12 years of age due to limited data in this age group.