Not to be used for mild GI complaints eg, nervous stomach. Exclude gastric malignancy prior to therapy. Increased risk of subacute cutaneous lupus erythematosus, osteoporosis-related hip, wrist & spine fractures, Clostridium difficile
-associated diarrhea. Presence of any alarm symptom eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena. Vit B12
malabsorption due to hypo- or achlorhydria; hypomagnesaemia. Discontinue use at least 5 day prior to CgA level measurement. Avoid sun exposure. Prolonged use. Ensure adequate intake of vit D & Ca. Concomitant use w/ digoxin or drugs causing hypomagnesemia eg, diuretics. Pregnancy & lactation. Not recommended in childn <12 yr. Elderly.