Pharmacology: Pharmacodynamics: Mechanism of Action: Paracetamol is a type of analgesic and antipyretic. Its mechanism functions are believed to include synthesis blocking prostaglandins, especially in the central nervous system.
Pharmacodynamic effects: Lack of peripheral blockage of prostaglandins results in important pharmacological properties such as preservation of prostaglandins which is protective in the gastrointestinal tract. Therefore, paracetamol is very suitable for patients who have history of disease or being in treatment, where prostaglandin peripheral restriction is not required (e.g., as for example, those with a history of gastrointestinal bleeding or the elderly).
Pharmacokinetics: Absorption: Paracetamol is absorbed rapidly and almost entirely from the gastrointestinal tract.
Distribution: Links to plasma proteins are minimal at therapeutic concentrations.
Metabolism: Paracetamol is metabolized in the liver and excreted in the urine mainly as glucuronide and sulfate conjugate.
Removal: Less than 5% was excreted as unmodified paracetamol.