500 mg: Paracetamol should also be given with care to patients taking other drugs that affect the liver.
Paracetamol hepatotoxicity has been reported to be enhanced by phenobarbitone, alcohol and doxorubicin.
650 mg: Contradictory pharmacokinetic results have been reported in patients receiving both chloramphenicol and paracetamol, ranging from increase to decrease and to no significant change in chloramphenicol half-life.
A combination of paracetamol and codeine has also enhanced warfarin anticoagulation activity.
Paracetamol has been reported to increase zidovudine's haematological toxicity.