Palonosetron - oral

Patient Medicine Information
Why do I need this medicine?
Palonosetron is used to prevent nausea and vomiting associated with cancer chemotherapy.
How do I take this medicine?
Take Palonosetron exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take Palonosetron with or without food, at least 1 hour before the start of your cancer chemotherapy.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember.

DO NOT double a dose under any circumstances.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • history of constipation
  • bowel problems
  • heart problems e.g. abnormal heart rhythm
  • electrolyte imbalance (imbalance of essential minerals in the body)
Let your doctor know if you are pregnant or breastfeeding.
What side effects could I experience?
Palonosetron may cause dizziness, drowsiness, or tiredness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects may include any of the following: headache, eye swelling, constipation, muscle pain, and difficulty sleeping.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of allergic reactions e.g. rashes, breathlessness, swelling of the face, eyes, or mouth
  • chest pain, shortness of breath, irregular or abnormal heartbeat
  • confusion, flushing, sweating, fever, muscle twitching and jerking, stiff muscles, fits or seizures
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • other medicines to prevent nausea and vomiting in cancer chemotherapy e.g. ondansetron, granisetron, dolasetron
  • medicines used to treat depression e.g. fluoxetine, sertraline, citalopram, venlafaxine, mirtazapine
  • strong painkillers e.g. fentanyl, tramadol
  • lithium (medicine for mood disorders)
This list does not include all medicines that may interact with Palonosetron.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from light.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on palonosetron - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
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