Palonosetron - Intravenous

Patient Medicine Information
Why do I need this medicine?
Palonosetron is used to prevent nausea and vomiting associated with cancer chemotherapy.

This medicine may also be used to prevent nausea and vomiting that may occur after surgery.
How do I use this medicine?
Palonosetron injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Palonosetron.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • history of constipation
  • bowel problems
  • heart problems e.g. abnormal heart rhythm
  • electrolyte imbalance (imbalance of essential minerals in the body)
Let your doctor know if you are pregnant or breastfeeding.
What side effects could I experience?
Palonosetron may cause dizziness, drowsiness, or tiredness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects may include any of the following: headache, eye irritation, constipation, diarrhoea, stomach pain or wind, joint pain, difficulty sleeping, and pain, discomfort or burning sensation at the injection site.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of allergic reactions e.g. rashes, breathlessness, swelling of the face, eyes, or mouth
  • chest pain, shortness of breath, irregular or abnormal heartbeat
  • confusion, flushing, sweating, fever, muscle twitching and jerking, stiff muscles, fits or seizures
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • other medicines to prevent nausea and vomiting in cancer chemotherapy e.g. ondansetron, granisetron, dolasetron
  • medicines used to treat depression e.g. fluoxetine, sertraline, citalopram, venlafaxine, mirtazapine
  • strong painkillers e.g. fentanyl, tramadol
  • lithium (medicine for mood disorders)
This list does not include all medicines that may interact with Palonosetron.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Protect from light. Do not freeze.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on Palonosetron - Intravenous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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