Oxiconazole: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Pityriasis versicolor

Adult: As 1% cream: Apply to affected areas once daily for 2 wk.

Topical/Cutaneous
Tinea corporis, Tinea cruris, Tinea pedis

Adult: As 1% cream or lotion: Apply to affected and immediately surrounding areas 1-2 times daily. Duration of treatment: 2 wk for tinea corporis and tinea cruris or 1 mth for tinea pedis.

Contraindications

Hypersensitivity.

Special Precautions

Pregnancy and lactation.

Adverse Reactions

Pruritus, burning, irritation, stinging, erythema, rash, folliculitis, papules, nodules, maceration, fissuring, scaling, tingling, pain, dyshidrotic eczema, contact dermatitis.

Pregnancy Category (US FDA)

Topical: B

Patient Counseling Information

Avoid contact w/ eyes or vagina.

Action

Description:
Mechanism of Action: Oxiconazole, a synthetic azole antifungal, is usually fungistatic but may be fungicidal in high concentrations. It exerts its antifungal activity by interfering w/ ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against aerobic gm+ve organisms.
Pharmacokinetics:
Absorption: Absorbed in each dermis layer. Very low systemic absorption.
Distribution: To each dermis layer.
Excretion: Via urine (<0.3%).

Chemical Structure

Storage

Store between 15-30°C.

MIMS Class

Preparations for Vaginal Conditions / Topical Antifungals & Antiparasites

References

Anon. Oxiconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 17/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Oxiconazole Nitrate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 17/07/2014.

Oxistat Cream, Lotion (PharmaDerm a division of Fougera Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 17/07/2014.

Wickersham RM. Oxiconazole Nitrate (Topical). Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 17/07/2014.

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