Orfarin

Orfarin

warfarin

Manufacturer:

Orion Pharma

Distributor:

Apex
Concise Prescribing Info
Contents
Warfarin Na
Indications/Uses
Treatment & prevention of DVT & pulmonary embolism. Prevention of thromboembolic complications (stroke or systemic embolism) after MI or in patients w/ atrial fibrillation, cardiac valvular disease or prosthetic heart valves.
Dosage/Direction for Use
Patient w/ normal wt, spontaneous INR <1.2 10 mg on 3 consecutive days. Open care, patient w/ inherited protein C or S deficiency Initially 5 mg in 3 days. Elderly, small size patient, spontaneous INR >1.2, w/ disease or on medication affecting anticoagulant therapy Initially 5 mg for 2 days. Childn w/ spontaneous INR 1-1.3 Initially 0.2 mg/kg on day 1.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Bleeding tendency (von Willebrand disease, hemophilia, thrombocytopenia, platelet function disorders); untreated or uncontrolled HTN; recent intracranial hemorrhage, other conditions predisposing to intracranial haemorrhage eg, aneurysms; tendency to fall; CNS or eye surgery; conditions predisposing to GI or urinary tract hemorrhage eg, previous GI bleeding complications, diverticulosis, malignancies; infectious endocarditis, pericarditis or pericardial effusion; dementia, psychoses, alcoholism. Severe hepatic insufficiency & hepatic cirrhosis. Pregnancy.
Special Precautions
Discontinue use if calciphylaxis is diagnosed. Protein C or S hereditary deficiency; hypo- & hyperthyroidism, fever, uncompensated heart failure; nephrotic syndrome; hyperphosphatemia, hypercalcaemia or hypoalbuminaemia. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucoseĀ­-galactose malabsorption. Renal & moderate hepatic insufficiency; ESRD on dialysis. Pregnancy. Elderly.
Adverse Reactions
Bleeding complications; nausea, vomiting, diarrhoea.
Drug Interactions
Reduced absorption or enterohepatic circulation w/ cholestyramine. Induced (eg, antiepileptics or antituberculotics) or inhibited (eg, amiodarone or metronidazole) hepatic metabolism. Pharmacodynamic interactions w/ drugs affecting platelets eg, ASA, clopidogrel, ticlopidine, dipyridamole, most NSAIDs. Severe bleeding conditions w/ large-dose penicillins. Potentiated effects w/ anabolic steroids, azapropazone, erythromycin, some cephalosporins; heavy alcohol use; quinine; cranberry juice, other cranberry products; ginkgo (Ginkgo biloba), garlic (Allium sativum), dong quai (Angelica sinensis), papaya (Carica papaya) or danshen (Salvia miltiorrhiza). Reduced effect w/ dietary vit K; ginseng (Panax spp), St. John's wort (Hypericum perforatum). Potentiated effects of oral sulphonylurea antidiabetics. Increased effect w/ ASA, allopurinol, amiodarone, amoxicillin, argatroban, azapropazone, azithromycin, bezafibrate, cabecitabine, carboxyuridine, celecoxib, clarithromycin, chloral hydrate, cefamandole, cefalexin, cefmenoxime, cefmetazole, cefoperazone, cefuroxime, cimetidine, ciprofloxacin, clofibrate, codeine, cyclophosphamide, dextropropoxyphene, dextrothyroxine, digoxin, disulfiram, doxycycline, erythromycin, etoposide, fenofibrate, feprazone, fluconazole, fluorouracil, flutamide, fluvastatin, fluvoxamine, gatifloxacin, gemfibrozil, grepafloxacin, ifosfamide, indometacin, flu vaccine, interferon α & β, INH, itraconazole, ketoconazole, latamoxef, leflunomide, lepirudin, levofloxacin, lovastatin, metolazone, MTX, metronidazole, miconazole, moxifloxacin, nalidixic acid, norfloxacin, ofloxacin, omeprazole, oxyphenbutazone, paracetamol, phenylbutazone, piroxicam, proguanil, propafenone, propranolol, quinine, quinidine, rofecoxib, roxithromycin, simvastatin, sulfafurazole, sulfamethizole, sulfamethoxazole-trimethoprim, sulfaphenazole, sulfinpyrazone, sulfofenur, sulindac, anabolic & androgenic steroid hormones, tamoxifen, tegafur, tetracycline, tolmetin, tramadol, trastuzumab, troglitazone, valproic acid, vit A & E, zafirlukast. Increased INR w/ noscapine, glucosamine. Decreased effect w/ azathioprine, barbiturates, carbamazepine, chlordiazepoxide, chlortalidone, cloxacillin, ciclosporin, dicloxacillin, disopyramide, griseofulvin, mercaptopurine, mesalazine, mitotane, nafcillin, nevirapine, phenobarb, primidone, rifampicin, spironolactone, trazodone, vit C. Vit K-containing foods eg, amaranth, chayote, kale, lettuce, mint & spinach leaf, avocado, broccoli, Brussels sprout, cabbage, canola, olive & soybean oil, chives, coriander, cucumber skin, endives, kiwifruit, mustard greens, parsley, peas, pistachio nuts, purple seaweed laver, spring onion, soybeans, tea leaves, turnip greens, watercress. Avoid use w/ methyl salicylate-containing topical prep.
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AA03 - warfarin ; Belongs to the class of vitamin K antagonists. Used in the treatment of thrombosis.
Presentation/Packing
Form
Orfarin tab 3 mg
Packing/Price
100's
Form
Orfarin tab 5 mg
Packing/Price
100's
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