CINV & RINV Adult 8 mg IV or IM prior to treatment, may be followed by 2 additional 8 mg IV or IM doses 2-4 hr apart or by constant 1 mg/hr infusion for up to 24 hr.
Highly emetogenic chemotherapy Max initial dose: 16 mg IV infused over 15 min, may be enhanced w/ single IV dose of dexamethasone Na phosphate 20 mg prior to chemotherapy.
Elderly ≥75 yr Initially not >8 mg infused over 15 min, may be followed by 2 doses of 8 mg infused over 15 min & given no <4 hr apart;
65-74 yr Initially 8 or 16 mg infused over 15 min, may be followed by 2 doses of 8 mg infused over 15 min & given no <4 hr apart.
CINV Childn & adolescent 3-17 yr, >1.2 m2 5 mg/m
2 or 8 mg IV + 8 mg tab after 12 hr on day 1, then 8 mg tab every 12 hr on days 2-6;
≥0.6 m2 to ≤1.2 m2 5 mg/m
2 IV + 4 mg tab after 12 hr on day 1, then 4 mg tab every 12 hr on days 2-6;
>10 kg Up to 3 doses of 0.15 mg/kg IV every 4 hr on day 1, then 4 mg tab every 12 hr on days 2-6.
Prevention & treatment of established PONV Adult 4 mg single IM dose or slow IV inj at anesth induction.
Childn & adolescent 3-17 yr 0.1 mg/kg by slow IV inj not <30 sec up to max: 4 mg prior to or after anesth induction, or after surgery.
Moderate or severe hepatic impairment Not to exceed 8 mg total daily dose.
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