IVEarly haemarthrosis, muscle or oral bleeding 20-40 IU/dL every 12-24 hr for at least 1 day until bleeding is resolved. More extensive haemarthrosis, muscle bleeding or haematoma 30-60 IU/dL every 12-24 hr for ≥3-4 days until bleeding is resolved. Life-threatening haemorrhage 60-100 IU/dL every 8-24 hr until bleeding is resolved. Minor surgery including tooth extraction 30-60 IU/dL every 24 hr for at least 1 day until healing is achieved. Major surgery (pre- & post-op) 80-100 IU/dL every 8-24 hr until adequate wound healing, then continue for at least another 7 days. Prophylaxis 20-40 IU/kg at 2-3 days interval.
Discontinue use if hypersensitivity reactions occur. Patients w/ existing CV risk factors; on controlled Na diet. Monitor for development of neutralizing Ab (inhibitors) especially in previously-untreated patients. Risk of central venous access device-related complications eg, local infections, bacteremia & catheter site thrombosis. Pregnancy & lactation.
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