Incompatibilities: Nexium: This medicinal product should not be used with other medicinal products except those mentioned in Instruction for use and handling as follows.
Nexium MUPS: Not applicable.
Instructions for Use and Handling: Nexium: The reconstituted solution should be inspected visually for particulate matter and discoloration prior to administration. Only clear solution should be used. For single use only.
If the entire reconstituted content of the vial is not required, any unused solution should be discarded in accordance with local requirements.
Injection 40 mg: A solution for injection 8 mg/ml is prepared by adding 5 ml of 0.9% sodium chloride for intravenous use to the esomeprazole 40 mg vial.
The reconstituted solution for injection is clear and colourless to very slightly yellow.
Infusion: Infusion 40 mg: A solution for infusion is prepared by dissolving the content of one vial with esomeprazole 40 mg in up to 100 ml of 0.9% sodium chloride for intravenous use.
Infusion 80 mg: A solution for infusion is prepared by dissolving the contents of two vials of esomeprazole 40 mg in up to 100 ml of 0.9% sodium chloride for intravenous use.
The reconstituted solution for infusion is clear and colourless to very slightly yellow.
Nexium MUPS: Administration through gastric tube: 1. Put the tablet into an appropriate syringe and fill the syringe with approximately 25 ml of water and approximately 5 ml air. For some tubes, dispersion in 50 ml water is needed to prevent the pellets from clogging the tube.
2. Immediately shake the syringe for approximately 2 minutes to disperse the tablet.
3. Hold the syringe with the tip up and check that the tip has not clogged.
4. Attach the syringe to the tube whilst maintaining the previous position.
5. Shake the syringe and position it with the tip pointing down. Immediately inject 5-10 ml into the tube. Invert the syringe after injection and shake (the syringe must be held with the tip pointing up to avoid clogging of the tip).
6. Turn the syringe with the tip down and immediately inject another 5-10 ml into the tube. Repeat this procedure until the syringe is empty.
7. Fill the syringe with 25 ml of water and 5 ml of air and repeat step 5 if necessary to wash down any sediment left in the syringe. For some tubes, 50 ml water is needed.