Epilepsy Adult & childn >12 yr 900-3,600 mg daily. Initially 300 mg tds on day 1 or by titrating dose as: 300 mg once daily on day 1, 300 mg bd on day 2, 300 mg tds on day 3. Thereafter, dose may be increased in 3 equally divided doses up to max: 3,600 mg daily.
Childn 3-12 yr Initially 10-15 mg/kg tds,
≥5 yr 25-35 mg/kg tds.
3 to <5 yr 40 mg/kg tds.
Neuropathic pain Adult 900 mg daily in 3 equally divided doses, increase if necessary up to max: 3,600 mg daily.
Renal impairment in patient w/ neuropathic pain or epilepsy CrCl ≥80 mL/min 900-3,600 mg daily,
50-79 mL/min 600-1,800 mg daily,
30-49 mL/min 300-900 mg daily,
15-29 mL/min 150-600 mg daily,
<15 mL/min 150-300 mg daily.
Patient undergoing hemodialysis Loading dose: 300-400 mg then 200-300 mg following each 4-hr hemodialysis.
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