Decreased AUC & C
max w/ etravirine (w/o boosted PIs), efavirenz, tipranavir/ritonavir, fosamprenavir/ritonavir, carbamazepine, rifampicin. Decreased levels w/ nevirapine, oxcarbazepine, phenytoin, phenobarb, St. John's wort. Increased AUC & C
max w/ atazanavir, atazanavir/ritonavir. Increased plasma conc of fampridine, metformin. Decreased AUC & C
max w/ Mg- & Al-containing antacids, Ca- & Fe supplements, multivit.