Dose-related bone marrow failure; male infertility, azoospermia & testicular atrophy. Leukaemia secondary to oncology chemotherapy; ILD; skin pigmentation. High-dose: Idiopathic pneumonia syndrome; nausea, vomiting, diarrhoea, mouth ulceration; hyperbilirubinaemia, jaundice, veno-occlusive liver disease, biliary fibrosis w/ hepatic atrophy & necrosis; ovarian disorder & amenorrhoea w/ menopausal symptoms in pre-menopausal patients, severe & persistent ovarian failure including pubertal failure. Cardiac tamponade; alopecia; haemorrhagic cystitis.