Molgramostim

Intravenous
Bone marrow transplantation

Subcutaneous
Ganciclovir-induced neutropenia

Subcutaneous
Chemotherapy-induced neutropenia

Intravenous:
Reconstitute the lyophilised powder with 1 ml of sterile water for inj. Further dilute the reconstituted solution in 25, 50 or 100 ml infusion bags or bottles of either normal saline solution or 5% dextrose in water. Infusion admixture solution should contain a final concentration of not <7 mcg/ml. Do not dilute below recommended min concentration (7 mcg/ml) since molgramostim solution may be adsorbed onto glass and plastic materials.
Subcutaneous:
Add 1 ml of diluent (bacteriostatic water for inj or sterile water for inj) to the vial. Do not dilute below recommended min concentration (7 mcg/ml) since molgramostim solution may be adsorbed onto glass and plastic materials.

Myeloid malignancies. Lactation.

Patients with any pre-malignant or malignant myeloid condition, pre-existing pulmonary disease. Discontinue use in patients who develop signs of pulmonary infiltrates. Patients with fluid retention or heart failure. Regularly monitor CBC during therapy. Pregnancy.

Fever and chills, nausea, dyspnoea, diarrhoea, rash, rigors, inj site reaction (SC admin), vomiting, fatigue, anorexia, bone and musculoskeletal pain, asthenia, transient hypotension, non-specific chest pain, stomatitis, headache, increased sweating, abdominal pain, pruritus, dizziness, peripheral oedema, paraesthesia and myalgia. Antibodies can develop.
Potentially Fatal: Anaphylactic reactions, pleural and pericardial effusion, cardiac arrhythmias.

Symptoms: Tachycardia, hypotension, flu-like syndrome. Treatment: Symptomatic.

May increase occurrence of bleomycin-induced pulmonary toxicity.
Potentially Fatal: Increased risk of myelosuppression when given simultaneously with myelosuppressive cytotoxic antineoplastics. Do not use within 24 hr of cytotoxic chemotherapy.

Description:
Mechanism of Action: Molgramostim is a granulocyte-macrophage colony-stimulating factor (GM-CSF) that influences the growth, differentiation and function of the granulocytes, macrophages and eosinophils. It helps in the separation of granulocyte and macrophage pathways and also enhances cell function.

Store at 2-8°C. Do not freeze. Protect from light.

Haematopoietic Agents / Supportive Care Therapy