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Indications and Dosage
Oral
Susceptible infections Adult: As acetate: 0.9-1.8 g daily in 2-3 divided doses.
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Administration
May be taken with or without food.
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Contraindications
Hypersensitivity. Patients who previously developed liver disorders while receiving the drug.
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Special Precautions
Hepatic or renal impairment; prolongation of QT interval; porphyria; pregnancy; lactation.
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Adverse Reactions
GI disturbances; hypersensitivity reactions; cholestatic jaundice; CV effects; myasthenia-like syndrome.
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Drug Interactions
Other drugs known to prolong QT interval. May reduce effect of oral contaceptives. Concentration possibly increased by cimetidine. Increased plasma concentration of warfarin, digoxin, theophylline, carbamazepine, ciclosporin. Increased risk of peripheral ischaemia with ergotamine.
Potentially Fatal: Ventricular arrhythmias with astemizole, terfenadine and cisapride. |
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Action
Description:
Mechanism of Action: Midecamycin binds reversibly to 50S ribosomal subunit causing blockade of transpeptidation/translocation reactions, inhibition of protein synthesis and thus inhibition of cell growth. Midecamycin has similar uses to erythromycin but is less active. |
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MIMS Class
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