Painful muscle spasm associated with acute musculoskeletal conditions
Adult: As an adjunct, for short-term symptomatic treatment: Dose is based on the severity of the condition and therapeutic response. Initially: 1,000 mg as a single dose. In severe cases or when oral therapy is not feasible: May give additional 1,000 mg 8 hourly; Max of 3,000 mg daily for no more than 3 consecutive days. If condition persists, may repeat course of treatment after a drug-free interval of 48 hours. Doses may be given via slow IV inj (Max rate of 300 mg/min), IV infusion; or deep IM inj (Max of 500 mg/gluteal region). Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Intravenous
Tetanus
Adult: As an adjunct, for management: Initially, 1,000-2,000 mg via direct IV inj. May give additional 1,000-2,000 mg via IV infusion, to give a total initial dose of up to 3,000 mg. Repeat dosage 6 hourly until nasogastric tube can be inserted. Treatment guidelines may vary among individual products and between countries (refer to specific product guidelines).
Child: As an adjunct, for management: Initially, 15 mg/kg or 500 mg/m2; may repeat 6 hourly if needed. Max total: 1,800 mg/m2 for 3 consecutive days. Treatment guidelines may vary among individual products and between countries (refer to specific product guidelines).
Child: As an adjunct, for management: Initially, 15 mg/kg or 500 mg/m2; may repeat 6 hourly if needed. Max total: 1,800 mg/m2 for 3 consecutive days. Treatment guidelines may vary among individual products and between countries (refer to specific product guidelines).
Oral
Painful muscle spasm associated with acute musculoskeletal conditions
Adult: As an adjunct, for short-term symptomatic treatment: Initially, 1,500 mg 4 times daily for 2-3 days (may give up to 8,000 mg daily in severe conditions). Usual maintenance dose: 2,250-4,500 mg daily in 3-4 divided doses. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Elderly: Dose reduction may be required.
Elderly: Dose reduction may be required.