Metadoxine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Acute alcohol intoxication

Adult: 500-1000 mg daily.

Oral
Alcoholic fatty liver, Supportive treatment of acute and chronic liver diseases

Adult: 1000 mg daily.

Parenteral
Acute alcohol intoxication

Adult: 300-600 mg daily IM/IV.

Parenteral
Alcoholic fatty liver, Supportive treatment of acute and chronic liver diseases

Adult: 300 mg daily IM/IV.

Contraindications

Pregnancy and lactation.

Drug Interactions

May reduce effects of levodopa; administer levodopa with a dopa-decarboxylase inhibitor to minimise interaction.

Action

Description:
Mechanism of Action: Metadoxine enhances the elimination of alcohol from blood and tissues, which leads to faster recovery from alcohol intoxication. In the early stages of alcoholic liver disease, metadoxine has been suggested to prevent the redox imbalance of the hepatocytes and to prevent TNF-α induction.

MIMS Class

Cholagogues, Cholelitholytics & Hepatic Protectors

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