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Indications and Dosage
Intramuscular
Severe hypoprothrombinaemia Adult: 2.5-10 mg daily. Intravenous Vitamin K deficiency Adult: 0.03 mcg/kg/day. Child: Infants: 1-5 mcg/kg/day. Oral Severe hypoprothrombinaemia Adult: 10 mg 3-4 times daily. Oral Vitamin K deficiency Adult: 10 mg every 6 hr.
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Special Precautions
Pregnancy. G6PD deficiency, vitamin E deficiency. Neonates, premature infants. Hepatic impairment. Monitor prothrombin time.
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Adverse Reactions
Facial flushing, sweating, chest constriction/pain, dyspnoea, cyanosis, CV collapse. IM: Severe shock-like reactions, phlebitis, inj site reactions.
Potentially Fatal: Anaphylaxis. |
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Drug Interactions
Decreases effects of oral anticoagulants.
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Action
Description:
Mechanism of Action: Menadione is a synthetic lipid-soluble vitamin K analogue. It is an essential cofactor in the hepatic synthesis of prothrombin (factor II) and other blood clotting factors (factors VII, IX, X and proteins C and S), and in the function of proteins important for bone development (e.g. osteocalcin). Pharmacokinetics: Absorption: Requires bile for absorption from the GI tract. Distribution: Accumulates in the liver; does not appear to cross the placenta. |
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MIMS Class
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