Adult 5 mg daily on the 1st wk, 10 mg daily on the 2nd wk then 15 mg daily on the 3rd wk & 20 mg daily from 4th wk. Max & maintenance dose: 20 mg daily. Elderly >65 yr 20 mg daily.
Hypersensitivity to bisulfites. Avoid use in patients whose urine pH is under monitoring eg, drastic changes in diet, ingestion of alkalizing gastric buffers, renal tubular acidosis, severe UTI w/ Proteus bacteria. Epilepsy, history of convulsions or predisposing factors of epilepsy. Not be taken by patients under medication of other NMDA antagonists eg, amantadine, ketamine or dextromethorphan. Pregnancy & lactation.
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