ibuprofen + paracetamol


AFT Pharma


Zuellig Pharma
Concise Prescribing Info
Paracetamol 500 mg, ibuprofen 150 mg
Temporary relief of pain associated w/ headache, migraine, backache, period, dental & muscular pain, cold & flu symptoms, sore throat & fever.
Dosage/Direction for Use
Adult & childn >12 yr 1-2 tab every 6 hr as required. Max: 8 tab in 24 hr.
Should be taken with food.
Hypersensitivity to aspirin, other NSAIDs. Patients who have experienced asthma, urticaria or allergic-type reactions after taking aspirin, ibuprofen or other NSAIDs; active GI bleeding, peptic ulceration or other stomach disorders; active alcoholism; heart problems. Renal & hepatic impairment. Pregnancy or planning to become pregnant. Lactation.
Special Precautions
Discontinue use if there is GI bleeding evidence. Not to be used in patients w/ aspirin-sensitive asthma. Regular haematological monitoring in patients on long-term therapy. Patients w/ underlying haemostatic defects, intrinsic coagulation defects, HTN, preexisting asthma, SLE or other connective tissue disorders. History of GI haemorrhage or peptic ulcer; upper GI ulcer, gross bleeding or perforation. Risk of serious CV events eg, MI & stroke. Severe skin reactions eg, exfoliative dermatitis, TEN & SJS. Perform ophth exam in patients who develop visual disturbance during therapy. May mask signs of infection. Not to be taken w/ ibuprofen-, paracetamol-, aspirin-, salicylate-containing products or any other anti-inflammatory products. Concomitant use w/ anticoagulants, aspirin, ACE inhibitors, angiotensin-receptor antagonists, thiazide diuretics. Avoid abrupt discontinuation in patients on prolonged corticosteroid therapy. Not to be used during pregnancy. Not recommended during lactation. Elderly >65 yr.
Adverse Reactions
Rarely, GI bleeding, dyspepsia, heartburn, nausea, loss of appetite, stomach pain, diarrhoea; dizziness, fatigue, headache, nervousness; skin rashes & itching; photosensitivity; risks of MI & stroke; fluid retention & oedema. Cutaneous hypersensitivity eg, angioedema, SJS/TEN.
Drug Interactions
Paracetamol: Dosage reduction w/ anticoagulants. Increased toxicity by antiepileptic medications. Increased absorption by gastric emptying increasing drugs eg, metoclopramide. Decreased absorption by gastric emptying decreasing drugs eg, propantheline, antidepressants w/ anticholinergic properties & narcotic analgesics. Increased chloramphenicol plasma conc. Increased toxicity w/ hepatotoxic drugs or liver microsomal enzyme inducers eg, alcohol & anticonvulsant agents. Affected excretion & plasma conc w/ probenecid. Reduced absorption w/ cholestyramine. Severe hepatotoxicity w/ INH alone or other TB drugs, zidovudine & co-trimoxazole. Ibuprofen: Increased risk of severe bleeding w/ anticoagulants eg, warfarin. Decreased renal clearance & increased plasma conc of lithium. Reduced antihypertensive effect of ACE inhibitors, β-blockers & diuretics. Reduced MTX clearance. Increased plasma levels of cardiac glycosides. Increased GI bleeding w/ corticosteroids. Prolonged bleeding time w/ zidovudine. Probenecid, antidiabetic medication, phenytoin.
MIMS Class
Analgesics (Non-Opioid) & Antipyretics / Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC Classification
N02BE51 - paracetamol, combinations excl. psycholeptics ; Belongs to the class of anilide preparations. Used to relieve pain and fever.
Maxigesic FC tab
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in