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Indications and Dosage
Oral
Pain and inflammation Adult: Up to 600 mg daily in divided doses. Rectal Pain and inflammation Adult: 400 mg bid.
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Contraindications
Hypersensitivity to NSAIDs or aspirin. Acute gastric ulcer.
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Special Precautions
Infections, asthma, allergic disorders, haemorrhagic disorders, hypertension. Elderly. Hepatic, renal and CV impairment.
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Adverse Reactions
Nausea, stomach discomfort, headache, dizziness, allergic skin reactions.
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Drug Interactions
Enhanced effects of oral anticoagulants, phenytoin and sulfonylureas. Increased plasma levels of lithium, methotrexate and cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus or diuretics. Increased risk of hyperkalaemia with ACE inhibitors and potassium-sparing diuretics. Reduced antihypertensive effects of ACE inhibitors, β-blockers and diuretics. Convulsions may occur when used with quinolones. Increased risk of adverse effects with other NSAIDs. Increased risk of GI bleeding and ulceration with corticosteroids, SSRIs, clopidogrel and ticlopidine. Increased risk of haematotoxicity with zidovudine.
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Action
Description:
Mechanism of Action: Lonazolac inhibits prostaglandin synthesis by decreasing the activity of the cyclooxygenase enzyme. |
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