Discontinue use if markedly elevated creatinine kinase (>5 x ULN) or ILD is suspected. Predisposing factors for rhabdomyolysis eg, hypothyroidism, history of hereditary muscular disorders or toxicity. Immune-mediated necrotising myopathy; DM. Perform LFTs prior to initiation & periodically thereafter. Avoid excessive alcohol consumption. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not to be co-administered w/ fusidic acid or w/in 7 days of discontinuation; erythromycin, other macrolide antibiotics. Concomitant use w/ myopathy-causing drugs eg, fibrates or niacin. May affect ability to drive & use machines. History of liver disease; hepatic & renal impairment. Women of childbearing potential should use effective contraception during treatment. Childn <6 yr. Elderly >70 yr.
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