Levemir

Levemir

insulin detemir

Manufacturer:

Novo Nordisk

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Insulin detemir, rDNA
Indications/Uses
DM in adults, adolescents & childn ≥1 yr.
Dosage/Direction for Use
SC Initially 0.1-0.2 U/kg or 10 U once daily or bd in combination w/ oral antidiabetics.
Administration
May be taken with or without food: For patients treated w/ once daily regimen, administer w/ evening meal or at bedtime. For patients who need bd dosing, the evening dose can be administered either w/ evening meal or at bedtime or 12 hr after morning dose.
Contraindications
Special Precautions
Not to be inj IV & avoid IM administration. Not to be used in insulin infusion pumps. Diabetic ketoacidosis; hyper- & hypoglycemia; concomitant illness, infections & feverish conditions; diseases affecting adrenal, pituitary or thyroid gland; lipodystrophy; cutaneous amyloidosis; inj site reactions. Physical activity, diet changes or during concomitant illness. Monitor blood glucose. Avoid accidental mix-ups w/ other insulin prep. Transferring to another type or brand of insulin. Combination w/ thiazolidinediones in CHF patients. May affect ability to drive & use machines. Renal or hepatic impairment. Intensified blood glucose control & monitoring during pregnancy. Dosage adjustment during lactation. Childn <1 yr. Elderly.
Adverse Reactions
Hypoglycaemia. Inj site reactions.
Drug Interactions
Reduced insulin requirement w/ oral antidiabetics, GLP-1 receptor agonists, MAOIs, β-blockers, ACE inhibitors, salicylates, anabolic steroids, sulphonamides. Increased insulin requirement w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone, danazol. Masked hypoglycaemia symptoms by β-blockers. Increased or decreased insulin requirement w/ octreotide/lanreotide. Intensified or reduced hypoglycaemic effect by alcohol.
MIMS Class
Insulin Preparations
ATC Classification
A10AE05 - insulin detemir ; Belongs to the class of long-acting insulins and analogues for injection. Used in the treatment of diabetes.
Presentation/Packing
Form
Levemir FlexPen (pre-filled pen) 100 IU/mL
Packing/Price
3 mL x 5 × 1's
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