Monotherapy for partial onset seizures w/ or w/o secondary generalisation in patients from 16 yr w/ newly diagnosed epilepsy. Adjunctive therapy for partial onset seizures w/ or w/o secondary generalisation in adults & childn from 4 yr w/ epilepsy; myoclonic seizures in adults & adolescents from 12 yr w/ juvenile myoclonic epilepsy; primary generalized tonic-clonic seizures in adults & adolescents from 12 yr w/ idiopathic generalised epilepsy.
MonotherapyAdult & adolescent from 16 yr Initially 250 mg bd, may be increased to 500 mg bd after 2 wk. May be further increased by 250 mg bd every 2 wk. Max: 1,500 mg bd. Add-on therapyAdult 18 yr & adolescent 12-17 yr, ≥50 kg Initially 500 mg bd, may be increased up to 1,500 mg bd. Dose changes can be made in 500 mg bd increases or decreases every 2-4 wk. Childn 4-11 yr & adolescent 12-17 yr, <50 kg Initially 10 mg/kg bd, may be increased up to 30 mg/kg bd. Dose changes not to exceed 10 mg/kg bd increases or decreases every 2 wk. Childn ≥50 kg Adult dose.
Increased risk of suicidal thoughts or behaviours. Avoid abrupt w/drawal. May affect ability to drive & use machines. Acute renal injury. Renal or severe hepatic impairment. Not to be used during pregnancy. Not recommended during lactation. Monotherapy treatment in childn & adolescents <16 yr. Tab: Not to be used in childn <6 yr & <25 kg.
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