Isoxsuprine

Oral
Cerebrovascular and peripheral vascular disease

May be taken with or without food. May be taken w/ meals, milk or antacids to minimise GI discomfort.

Recent arterial haemorrhage.

Pregnancy and lactation. Not intended to be given immediately postpartum.

Significant: Severe rash.
Nervous: Trembling, nervousness, weakness, dizziness.
CV: Palpitation, tachycardia, chest pain, hypotension, flushing.
GI: Abdominal distress, nausea, vomiting, intestinal distention.

IV/Parenteral/PO: C

Description:
Mechanism of Action: Isoxsuprine, a β-agonist, increases muscle blood flow by directly relaxing the vascular smooth muscle.
Pharmacokinetics:
Absorption: Well absorbed from the GI tract. Time to peak plasma concentration: Approx 1 hr.
Distribution: Crosses the placenta.
Excretion: Excreted via urine as conjugates. Plasma elimination half-life: Approx 1.5 hr.

Source: National Center for Biotechnology Information. PubChem Database. Isoxsuprine, CID=3783, https://pubchem.ncbi.nlm.nih.gov/compound/Isoxsuprine (accessed on Jan. 21, 2020)

Store between 15-30°C.

Peripheral Vasodilators & Cerebral Activators

C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.

Anon. Isoxsuprine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/07/2017.

Buckingham R (ed). Isoxsuprine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/07/2017.

Isoxsuprine Hydrochloride Tablets (Vista Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/07/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Isoxsuprine Hydrochloride. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 10/07/2017.