Isepamicin: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Parenteral
Susceptible infections

Adult: Up to 15 mg/kg daily by IM injection or IV infusion in 2 divided doses. Adjust dose based on serum isepamicin conc monitoring. Total dose should not exceed 1.5 g/day.

Contraindications

Pregnancy; hypersensitivity.

Special Precautions

Myasthenia gravis; regular assessment of auditory and renal function is necessary in patients with additional risk factors. Cystic fibrosis, obesity.

Adverse Reactions

Ototoxicity; nephrotoxicity; electrolyte disturbances; respiratory depression; muscular paralysis; cross-sensitivity with other aminoglycosides.

Drug Interactions

Other nephrotoxic drugs eg, vancomycin, cephalosphorins, ciclosporin, cisplatin and fludarabine; potentially ototoxic drugs eg, ethacrynic acid, furosemide; neuromuscular-blocking agents; general anesthetics; opioids; β-lactams; dimenhydrinate.

Action

Description:
Mechanism of Action: Isepamicin is a semisynthetic aminoglycoside which inhibits protein synthesis by binding to 30s and 50s ribosomal subunits in susceptible bacteria.

MIMS Class

Aminoglycosides

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