Possibility of permanent heterochromia. Chronic angle-closure glaucoma or open-angle glaucoma of pseudophakic patients & pigmentary glaucoma; inflammatory, neovascular & congenital glaucoma, inflammatory ocular conditions; acute attacks of closed-angle glaucoma. Avoid use in active herpes simplex keratitis & patients w/ history of recurrent herpetic keratitis associated w/ prostaglandin analogues; history of herpetic keratitis. Aphakic & pseudophakic patients w/ torn posterior lens cap or anterior chamber lenses, or known risk factors for cystoid macular oedema; iritis or uveitis; asthma. Patients during peri-op period of cataract surgery. Eye irritation due to benzalkonium Cl. Remove contact lens prior to application & wait 15 min before reinsertion. May impair ability to drive & use machines. Not to be used during pregnancy & lactation. Ped <1 yr & preterm infants <36 wk gestation.
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