Hypothyroidism; decreased appetite; headache, dysgeusia; HTN, haemorrhage; dyspnoea, cough, dysphonia; diarrhoea, vomiting, nausea, abdominal pain, constipation, stomatitis, dyspepsia; palmar-plantar erythrodysaesthesia, rash, dry skin; arthralgia, pain in extremity; proteinuria; fatigue, asthenia, mucosal inflammation; decreased wt. Anaemia, thrombocytopenia, polycythaemia; hyperthyroidism; dehydration, hyperkalaemia, hypercalcaemia; dizziness, tinnitus; cardiac failure events, venous & arterial embolic & thrombotic events; oropharyngeal pain, upper abdominal pain, flatulence, haemorrhoids, glossodynia, GI perforation & fistula; hyperbilirubinaemia, cholecystitis; pruritus, erythema, alopecia; myalgia; renal failure; increased lipase, ALT, amylase, AST, alkaline phosphatase, creatinine & TSH.