NSCLC Patient >30 kg 10 mg/kg IV infusion over 60 min every 2 wk or 1,500 mg IV infusion over 60 min every 4 wk until disease progression, unacceptable toxicity or max: 12 mth,
patient ≤30 kg 10 mg/kg IV infusion over 60 min every 2 wk until wt increase to >30 kg.
ES-SCLC Patient >30 kg 1,500 mg IV infusion over 60 min in combination w/ chemotherapy every 3 wk for 4 cycles, followed by 1,500 mg every 4 wk as monotherapy until disease progression or unacceptable toxicity,
patient ≤30 kg 20 mg/kg IV infusion over 60 min in combination w/ chemotherapy every 3 wk for 4 cycles, followed by 20 mg/kg every 4 wk as monotherapy until wt increase to >30 kg.
BTC Patient >36 kg 1,500 mg IV infusion over 60 min in combination w/ chemotherapy every 3 wk for 8 cycles, followed by 1,500 mg every 4 wk as monotherapy until disease progression or unacceptable toxicity,
patient ≤36 kg 20 mg/kg IV infusion over 60 min in combination w/ chemotherapy every 3 wk for 8 cycles, followed by 20 mg/kg every 4 wk until wt increase to >36 kg.