Hypersensitivity. Rhinitis sicca. Adult & Childn nasal drops: Chronic rhinitis; increased IOP especially narrow-angle glaucoma; severe CV diseases eg, CHD, HTN; phaeochromocytoma; metabolic disorders eg, hyperthyroidism, DM, porphyria; prostatic hyperplasia. Patients treated w/ drugs w/ hypertensive effect (eg, MAOIs & TCAs) potentially lead to increased BP due to their CV activity. May cause skin irritation due to benzalkonium Cl. Infant nasal drops: Premature or underwt newborns to avoid risk of overdosage.