Increased plasma conc w/ strong CYP3A inhibitors eg, clarithromycin, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole; grapefruit/grapefruit juice. Decreased plasma conc w/ strong CYP3A inducers eg, phenytoin, rifampin, carbamazepine, enzalutamide, St. John's wort. Increased exposure of midazolam, alfentanil, cyclosporine, dihydroergotamine, ergotamine, everolimus, fentanyl, pimozide, quinidine, sirolimus, tacrolimus.