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Indications and Dosage
Inhalation/Respiratory
Relief of bronchoconstriction Adult: As sulfate: 100-200 mcg up to 6 times/day by aerosol inhalation. As HCl: 250-500 mcg every 4-6 hr by nebulisation; max: 3 mg/day for nebulisation. Intravenous Premature labour Adult: As sulfate: slow IV Inj of 10 mcg loading dose over 5-10 minutes, followed by an initial infusion rate of 0.3 mcg/minute. Prolonged infusion at 0.075 mcg/minute may be given if there is no cervical change. Oral Relief of bronchoconstriction Adult: 0.5-1 mg tid.
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Administration
Should be taken on an empty stomach. Take 30 min before meals.
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Contraindications
Heavy genital haemorrhage, premature separation of the placenta, intra-uterine infections, severe myocardial insufficiency.
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Special Precautions
CV disorders including heart disease, severe hypertension and hypotension, hyperthyroidism, DM, patients who respond unusual to sympathomimetics. Thyrotoxicosis, tachycardiac arrhythmias, myocarditis, hypotension, severe renal disease, mitral valve defects, idiopathic hypertrophic subvalvular aortic stenosis. Risk of pulmonary oedema in patients being treated for premature labor. Pregnancy, lactation.
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Adverse Reactions
Occasionally, tachycardia. Palpitation and skeletal muscle tremor (on high and cumulative doses).
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Drug Interactions
MAOIs, TCAs, β-blockers, calcium- and vitamin D-containing preparations, dihydrotachysterol, mineralocorticoids, methylxanthines, glucocorticoids.
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Action
Description:
Mechanism of Action: Hexoprenaline is a direct-acting sympathomimetic with predominantly β-adrenergic activity selective to β2-receptors. |
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