Heptral Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Ademetionine

Indications/Uses

Intrahepatic cholestasis in pregnancy & in precirrhotic & cirrhotic states. Relief of fatigue caused by chronic liver disease.

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Dosage/Direction for Use

Adult Intrahepatic cholestasis Recommended dose: 10-25 mg/kg daily. Usual starting dose: 800 mg daily. Total daily dose: 1,600 mg. Maintenance: 800-1,600 mg daily.

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Overdosage

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Administration

Should be taken on an empty stomach: Swallow whole, do not chew/crush.

Contraindications

Hypersensitivity.

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Special Precautions

Monitor ammonia levels in patients w/ hyperammonemia in precirrhotic & cirrhotic states. Routine blood test to check plasma levels of ademetionine in patients at risk of vit B₁₂ & folate deficiencies. May affect ability to drive or operate machinery. Renal impairment. Pregnancy & lactation. Childn. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

UTI; confusion, insomnia; dizziness, headache, paresthesia; CV disorder; hot flush, superficial phlebitis; abdominal distension & pain, diarrhea, dry mouth, dyspepsia, esophagitis, flatulence, GI pain & hemorrhage, nausea, vomiting; biliary colic, hepatic cirrhosis; hyperhydrosis, pruritus, skin reactions; arthralgia, muscle spasms; asthenia, chills, inj site reactions, flu-like illness, malaise, peripheral edema, pyrexia.

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Drug Interactions

Serotonin syndrome w/ clomipramine. SSRIs, TCAs, tryptophan-containing over-the-counter drugs & herbal supplements.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Heptral detailed prescribing information

Storage

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Description

View Heptral description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Cholagogues, Cholelitholytics & Hepatic Protectors

ATC Classification

A16AA02 - ademetionine ; Belongs to the class of amino acids and derivatives products. Used in treatment of alimentary tract and metabolism problems.

Regulatory Classification

Presentation/Packing

Form

Heptral gastro-resistant tab 500 mg

Packing/Price

2 × 10's

Heptral

Manufacturer:

Abbott

Distributor:

Zuellig Pharma