Granodex

Granodex Special Precautions

granisetron

Manufacturer:

Dexa Medica

Distributor:

Averroes Pharma
Full Prescribing Info
Special Precautions
As granisetron may reduce lower bowel motility, patients with signs of subacute intestinal obstruction should be monitored closely following administration of granisetron.
As with other 5-HT3 antagonists, cases of ECG modifications including QT prolongation have been reported with granisetron. These ECG changes with granisetron were minor and generally not of clinical significance, specifically with no evidence of proarrhythmia. However, in patients with pre-existing arrhythmias or cardiac conduction disorders, this might lead to clinical consequences. Therefore, caution should be exercised in patients with cardiac co-morbidities, on cardiotoxic chemotherapy and/or with concomitant electrolyte abnormalities. Cross-sensitivity between 5-HT3 antagonists has been reported.
As with other 5-HT3 antagonists, cases of serotonin syndrome (including altered mental status, autonomic dysfunction and neuromuscular abnormalities) have been reported following the concomitant use of granisetron and other serotonergic drugs. If concomitant treatment with granisetron and other serotonergic drugs is clinically warranted, appropriate observation of this patient is advised.
Effects on ability to drive and use machines: Granisetron has no or negligible influence on the ability to drive or to use machines.
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