Granodex

Granodex Drug Interactions

granisetron

Manufacturer:

Dexa Medica

Distributor:

Averroes Pharma
Full Prescribing Info
Drug Interactions
Hepatic enzyme induction with phenobarbital resulted in an increase in total plasma clearance of intravenous granisetron of approximately one-quarter.
Ketoconazole inhibited ring oxidation of granisetron. However, given the absence of pK/pD relationship with granisetron, these changes are believed to have no clinical consequences.
Granisetron has been safely administered in humans with benzodiazepines, neuroleptics and antiulcer medications, commonly prescribed with antiemetic treatments. Additionally, granisetron has shown no apparent drug interaction with emetogenic cancer chemotherapies.
No specific interaction studies have been conducted in anesthetized patients, but granisetron has been safely administered with commonly used anesthetic and analgesic agents. In addition, the activity of the cytochrome P450 subfamily 3A4 (involved in the metabolism of some of the main narcotic analgesic agents) is not modified by granisetron.
As for other 5-HT3 antagonists, cases of ECG modifications including QT prolongation have been reported with granisetron. These ECG changes with granisetron were minor and generally not of clinical significance, specifically with no evidence of proarrhythmia. However, in patients concurrently treated with drugs known to prolong QT interval and/or are arrhythmogenic, this may lead to clinical consequences.
As with other 5-HT3 antagonists, cases of serotonin syndrome have been reported following the concomitant use of granisetron and other serotonergic drugs. If concomitant treatment with granisetron and other serotonergic drugs is clinically warranted, appropriate observation of this patient is advised.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in