Adult: Monotherapy or adjunctive treatment for the symptomatic relief of mild to moderate cases: As glucosamine hydrochloride tab/effervescent tab/cap: Usual dose: 1,250 mg once daily, as a single dose or in 2 divided doses. As glucosamine sulfate tab/powder for oral solution: Usual dose: 1,500 mg once daily, as a single dose or in 2-3 divided doses. Re-evaluate treatment if relief of symptoms is not achieved after 2-3 months.
Should be taken with food. Preferably taken at meals.
Effervescent tab: Dissolve in at least 100 mL of water. Powder for oral solution: Dissolve in at least 250 mL of water.
Hypersensitivity to glucosamine and shellfish. Children.
Patient with impaired glucose tolerance, diabetes mellitus, asthma; known risk factors for CV disease. Rule out the presence of other joint diseases. Not indicated for the treatment of acute painful symptoms. Renal and hepatic impairment. Pregnancy and lactation.
May increase the anticoagulant effects of warfarin and acenocoumarol. May increase the absorption and serum levels of tetracyclines.
Description: Mechanism of Action: Glucosamine is a natural substance found in mucoproteins, chitin, and mucopolysaccharides. It stimulates the synthesis of glycosaminoglycans which are responsible for the formation of cartilage in the body. It may be used as a health supplement in the management of musculoskeletal and joint disorders for its supposed chondroprotective activity. Pharmacokinetics: Distribution: Volume of distribution: Approx 2.5-5 L. Metabolism: Extensively metabolised in the liver. Excretion: Via urine.
Store below 30°C. Protect from light and moisture.